Health information technology (HIT) plays a vital role in augmenting users’ health conditions and facilitating the self-management of health. Mobile health apps (MHAs) are a type of HIT that run on mobile devices (e.g., wearables and mobile phones). Their primary role is to instruct users on proper food intake. The existing literature has not examined how these devices help users learn to make safe food choices. Based on the technology affordance theory and the theory of reasoned action, this research presents a model for users’ safe food choice behavior in MHA. This study reveals how MHA influences a user’s safe food choice decision. Through empirical research, the results of this study report that the technology affordance of MHA has a significant positive impact on safe food knowledge acquisition and provision, which in turn influences attitudes toward safe food consumption. The attitude affects users’ safe food choice intentions. We discuss the theoretical and practical implications of examining the process by which people learn to make safe food choices using MHAs.