This article outlines a number of important research issues in human-computer interaction in the e-commerce environment. It highlights some of the challenges faced by users in browsing Web sites and conducting searches for information, and suggests several areas of research for promoting ease of navigation and search. Also, it discusses the importance of trust in the online environment, describing some of the antecedents and consequences of trust, and provides guidelines for integrating trust into Web site design. The issues discussed in this article are presented under three broad categories of human-computer interaction – Web usability, interface design, and trust – and are intended to highlight what we believe are worthwhile areas for future research in e-commerce.